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November 19th, For work toward a safer approach to treating cancer, electrical engineering Ph. This kind of targeted drug delivery minimizes collateral damage to non-cancerous cells. Preclinical trials for a number of cancer types including colorectal cancer, pancreatic cancer, acute lymphoblastic leukemia, and metastatic breast cancer are under way and clinical studies will follow, according to Ortac.

The nano-wiffle-ball approach can be applied for the treatment of solid and liquid tumors as well as metastatic cancers. For solid tumors the nano-wiffle-balls, which are nano-scale mesopores capsules made of silica, are first filled with foreign enzymes and the mesopores are sealed. Trillions of nano-wiffle balls loaded with foreign enzymes can be directly injected near the tumor site or would be delivered systematically travelling through the blood stream and accumulate at the cancer sites.

This accumulation at cancer sites occurs, in large part, due to enhanced permeability and retention effects caused by the incomplete, and therefore leaky, nature of the vasculature around tumor tissue.

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When the prodrug comes into contact with the nano-wiffle balls, the prodrug small molecule enters these nano-capsules and reacts with the enzyme cargo. These reactions activate the prodrug, turning it into an active cancer-fighting drug.

In this way, the drugs are delivered just to the cancer sites where the nano-wiffle-balls accumulate. The prodrug is designed to react only with these foreign enzymes, eliminating the potential for the unwanted activation of the drug elsewhere in the body.

This application is being investigated in collaboration with Prof. Using foreign enzymes, however, means that they are likely to provoke an immune system response aimed at neutralizing and removing the enzymes from the body.

To avoid this immune response, the researchers encapsulate the foreign enzymes within the nano-wiffle-balls in order to hide the enzymes. In addition, nano-wiffle-balls offer low toxicity, high loading capacity, and significant control in their physical parameters.

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Nano-wiffle-balls can be modified with molecular agents to improve the targeting and retention at the tumor site. During his time at the Jacobs School of Engineering, Ortac has been no stranger to the process of technology commercialization.

InOrtac, Ahmet Erten Ph. Your email address will not be published. Nano-Wiffle-Ball Therapy The nano-wiffle-ball approach can be applied for the treatment of solid and liquid tumors as well as metastatic cancers.

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